HOLOXANE

This brand name is authorized in Brazil

Active ingredients

The drug HOLOXANE contains one active pharmaceutical ingredient (API):

1 Ifosfamide
UNII UM20QQM95Y - IFOSFAMIDE

Ifosfamide is an antineoplastic, a cytotoxic alkylating agent. It is a prodrug and shows no in vitro cytotoxic activity until activated by microsomal enzymes. The cytotoxic activity of ifosfamide (alkylation of the nucleophilic centres in the cells) is associated with the activated oxazaphosphorine ring hydroxylated at the C4 atom which interacts with DNA-DNA cross linking. This activity manifests itself by blocking the late S and early G2 phases of the cell cycle.

Read about Ifosfamide

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01AA06 Ifosfamide L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AA Nitrogen mustard analogues
Discover more medicines within L01AA06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: BR Cรขmara de Regulaรงรฃo do Mercado de Medicamentos Identifier(s): 503205301157411, 503205302153411, 503205303151410, 503217020029303, 503217020029403, 503217020029503

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