Influenza

Active Ingredient: Baloxavir marboxil

Indication for Baloxavir marboxil

Population group: only adolescents (12 years - 18 years old) , adults (18 years old or older)
Therapeutic intent: Curative procedure

Baloxavir marboxil is indicated for the treatment of uncomplicated influenza in patients aged 12 years and above.

For this indication, competent medicine agencies globally authorize below treatments:

40 mg once for patients weighting <80 kg and 80 mg once weighting ≥80 kg

For:

Dosage regimens

Regimen A: In case that patient weight is ≤ 80 kg, oral, 40 milligrams baloxavir marboxil, one dose.

Regimen B: In case that patient weight is ≥ 80 kg, oral, 80 milligrams baloxavir marboxil, one dose.

Detailed description

A single dose of baloxavir marboxil should be taken as soon as possible within 48 hours of symptom onset.

Adults and adolescents (≥12 years of age)

The recommended oral dose of baloxavir marboxil depending on body weight is shown in the following table.

Baloxavir marboxil dosing by patient weight:

Patient body weight Recommended oral dose
<80 kg Single dose of 40 mg taken as
2 × 20 mg tablets
≥80 kg Single dose of 80 mg taken as
2 × 40 mg tablets

There are no clinical data on the use of a repeat dose of baloxavir marboxil for the treatment of uncomplicated influenza.

Dosage considerations

The tablets should be taken with water.

Baloxavir marboxil may be taken with or without food.

Baloxavir marboxil should not be taken with products that contain polyvalent cations such as laxatives, antacids or oral supplements containing iron, zinc, selenium, calcium or magnesium.

Active ingredient

Baloxavir marboxil

Baloxavir marboxil is a prodrug that is converted by hydrolysis to baloxavir, the active form that exerts anti-influenza activity. Baloxavir acts on the cap-dependent endonuclease (CEN), an influenza virus-specific enzyme in the polymerase acidic (PA) subunit of the viral RNA polymerase complex and thereby inhibits the transcription of influenza virus genomes resulting in inhibition of influenza virus replication.

Read more about Baloxavir marboxil

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