Active Ingredient: Capecitabine
Capecitabine is indicated for the treatment of:
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2,500 mg per m² of body surface area (BSA)
1,250 mg per m² of body surface area (BSA) 2 time(s) per day every day for 14 day(s)
Given as monotherapy, the recommended starting dose for capecitabine in the adjuvant treatment of colon cancer, in the treatment of metastatic colorectal cancer or of locally advanced or metastatic breast cancer is 1250 mg/m² administered twice daily (morning and evening; equivalent to 2500 mg/m² total daily dose) for 14 days followed by a 7-day rest period. Adjuvant treatment in patients with stage III colon cancer is recommended for a total of 6 months.
Should be swallowed with water within 30 minutes after a meal.
Oral
2,500 mg per m² of body surface area (BSA)
1,250 mg per m² of body surface area (BSA) 2 time(s) per day every day for 14 day(s)
In combination with docetaxel, the recommended starting dose of capecitabine in the treatment of metastatic breast cancer is 1250 mg/m² twice daily for 14 days followed by a 7-day rest period, combined with docetaxel at 75 mg/m² as a 1 hour intravenous infusion every 3 weeks. Premedication with an oral corticosteroid such as dexamethasone according to the docetaxel summary of product characteristics should be started prior to docetaxel administration for patients receiving the capecitabine plus docetaxel combination.
Should be swallowed with water within 30 minutes after a meal.
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