Perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, urticaria, angioedema

Active Ingredient: Dexchlorpheniramine

Indication for Dexchlorpheniramine

Dexchlorpheniramine is indicated for symptomatic treatment of perennial and seasonal allergic rhinitis, vasomotor rhinitis, allergic conjunctivitis, mild uncomplicated allergic skin manifestations of urticaria and angioedema. Dexchlorpheniramine may relieve itching due to skin conditions such as allergic eczema, pruritus ani, pruritus vulvae, atopic dermatitis, contact dermatitis, insect bites, dermographism and medicine reactions, including serum sickness.

For this indication, competent medicine agencies globally authorize below treatments:

2 mg every 6 hours

For:

Dosage regimens

Oral, 2 milligrams dexchlorpheniramine, once every 6 hours.

0.5-1.6 mg every 6-8 hours

For:

Dosage regimens

Oral, between 0.4 milligrams dexchlorpheniramine and 1.6 milligrams dexchlorpheniramine, once every 6 to 8 hours.

Active ingredient

Dexchlorpheniramine
Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H₁-receptor sites, and competitively antagonizes the effects of histamine on H₁-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H₁-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H₁-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects. Read more about Dexchlorpheniramine

Related medicines

Summary of Product Characteristics (SPC) 2017: POLARAMINE Film-coated tablet / Syrup

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