Brachial plexus block

Active Ingredient: Chloroprocaine

Indication for Chloroprocaine

Population group: only adults (18 - 65 years old)

For this indication, competent medicine agencies globally authorize below treatments:

600-800 mg once

For:

Dosage regimens

Perineural, between 600 milligrams chloroprocaine and 800 milligrams chloroprocaine, one dose.

Detailed description

Posology

Posology must be established on an individual basis in accordance with the characteristics of the specific case. When determining the dose, the patient’s physical condition and the concomitant administration of other medicinal products should be taken into consideration.

The dose administered varies with the anaesthetic procedure, the vascularity of the tissues, the depth of anaesthesia and degree of muscle relaxation required, the duration of anaesthesia desired, and the physical condition of the patient.

The following table is a guide to dosage for the more commonly used blocks. The smallest dose required to produce an effective block should be used.

Posology Adults

Anaesthetic ProcedureVolume (ml) Total dose (mg)
Major Nerve Blocks*
Axillary block
Brachial plexus block
Femoral block
Sciatic block
15-40
20
30-40
15-30
20-30
300-800
400
600-800
300-600
400-600
Minor Nerve Blocks
Peribulbar block
Infraorbital block
0.5-5
5
0.5-1
10-100
100
10-20

* With regard to major nerve block, only for axillary block a dose recommendation can be given. There is presently no experience of specific dose recommendations for other blocks and the posology must be established on an individual basis

The maximum recommended dose in adults is 11 mg/kg, not to exceed a maximum total dose of 800mg (=40ml) of chloroprocaine hydrochloride.

The duration of action is dose-dependent.

Active ingredient

Chloroprocaine

Chloroprocaine is procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. Chloroprocaine, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine.

Read more about Chloroprocaine

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