Soft tissue sarcoma

Active Ingredient: Melphalan

Indication for Melphalan

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

0.6-1.4 mg/kg once

Route of admnistration

Intra-arterial

Defined daily dose

0.6 - 1.4 mg per kg of body weight

Dosage regimen

From 0.6 To 1.4 mg per kg of body weight once every day for 1 day(s)

Detailed description

Hyperthermic regional perfusion with melphalan has been used in the management of all stages of localized soft tissue sarcoma, usually in combination with surgery.

Active ingredient

Melphalan

Melphalan is a bifunctional alkylating agent. Formation of carbonium intermediates from each of the two bis-2-chloroethyl groups enables alkylation through covalent binding with the 7-nitrogen of guanine on DNA, cross-linking the two DNA strands and thereby preventing cell replication.

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