Spasticity of voluntary muscle

Indication for Baclofen

Population group: Suitable for both men and women, only minors (0 - 18 years old)

Baclofen is indicated in patients 0 to <18 years for the symptomatic treatment of spasticity of cerebral origin, especially where due to infantile cerebral palsy, as well as following cerebrovascular accidents or in the presence of neoplastic or degenerative brain disease.

Baclofen is also indicated for the symptomatic treatment of muscle spasms occurring in spinal cord diseases of infectious, degenerative, traumatic, neoplastic, or unknown origin such as multiple sclerosis, spastic spinal paralysis, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, traumatic paraplegia or paraparesis, and compression of the spinal cord.

For this indication, competent medicine agencies globally authorize below treatments:

0.3-2.0 mg/kg in 2-4 divided doses daily

Route of admnistration


Defined daily dose

0.3 - 2 mg per kg of body weight

Dosage regimen

From 0.075 To 0.5 mg per kg of body weight 4 time(s) per day every day

Detailed description

Treatment should usually be started with a very low dose (corresponding to approximately 0.3 mg/kg a day), in 2-4 divided doses (preferably in 4 divided doses). The dosage should be raised cautiously, at about 1 week intervals, until it becomes sufficient for the child’s individual requirements. The usual daily dosage for maintenance therapy ranges between 0.75 and 2 mg/kg body weight. The total daily dose should not exceed a maximum of 40 mg/day in children below 8 years of age. In children over 8 years of age, a maximum daily dose of 60 mg/day may be given.

Baclofen tablets are not suitable for use in children below 33 kg body weight.

Dosage considerations

Baclofen should be taken during meals with a little liquid.

Active ingredient

Baclofen is an antispastic agent acting at the spinal level. A gamma-aminobutyric acid (GABA) derivative, chemically unrelated to other antispastic agents.

Read more about Baclofen

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