Acne vulgaris

Active Ingredient: Adapalene

Indication for Adapalene

Population group: only adolescents (12 years - 18 years old) , adults (18 - 65 years old)

Adapalene is proposed for the cutaneous treatment of mild to moderate acne vulgaris where comedones, papules and pustules predominate. Acne of the face, chest or back is appropriate for treatment. 2

For this indication, competent medicine agencies globally authorize below treatments:

once a day before retiring

Route of admnistration

Cutaneous

Defined daily dose

1 {spreads}

Dosage regimen

1 {spreads} once every day

Detailed description

Adapalene Cream should be applied to the acne affected areas once a day before retiring and after washing.

Since it is customary to alternate therapies in the treatment of acne, it is recommended that the physician assess the continued improvement of the patient after three months of treatment with adapalene Cream.

With patients for whom it is necessary to reduce the frequency of application or to temporarily discontinue treatment, frequency of application may be restored or therapy resumed once it is judged that the patient can again tolerate the treatment.

If patients use cosmetics, these should be non-comedogenic and non-astringent.

Paediatric population: The safety and effectiveness of Differin Cream have not been studied in children below 12 years of age.

Dosage considerations

A thin film of cream should be applied, with the fingertips, avoiding the eyes and lips. Ensure that the affected areas are dry before application.

Active ingredient

Adapalene

Adapalene is a retinoid-like compound which in, in vivo and in vitro models of inflammation, has been demonstrated to possess anti-inflammatory properties. Mechanically, adapalene binds like tretinoin to specific retinoic acid nuclear receptors but, unlike tretinoin not to cytosolic receptor binding proteins. Adapalene is used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions.

Read more about Adapalene

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