Active Ingredient: Spironolactone
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 100 milligrams spironolactone and 200 milligrams spironolactone, once daily to meals.
Usual dose – 100 mg/day to 200 mg/day. Spironolactone has not been shown to be anti-inflammatory, nor to affect the basic pathological process. Its use is only advised if glucocorticoids by themselves are insufficiently effective.
It is recommended that treatment is started with the lowest dose and titrated upwards as required to achieve maximum benefit. Care should be taken in severe hepatic and renal impairment which may alter spironolactone metabolism and excretion.
Spironolactone should be taken together with a meal.
For:
Oral, between 1 milligrams spironolactone per kilogram of body weight and 3 milligrams spironolactone per kilogram of body weight, divided 1 to 2 times daily to meals.
Infant or child 1 month to 18 years: 1-3 mg/kg daily in 1-2 divided doses (maximum 200 mg daily).
Treatment should only be taken under the guidance of a specialist paediatrician. There is limited paediatric data available.
Spironolactone should be taken together with a meal.
For:
Oral, between 1 milligrams spironolactone per kilogram of body weight and 2 milligrams spironolactone per kilogram of body weight, divided 1 to 2 times daily to meals.
Neonates should only be treated under guidance of a paediatric specialist. There is limited paediatric data available.
Spironolactone should be taken together with a meal.
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