Squamous Cell Cancer of the Head and Neck (SCCHN)

Active Ingredient: Nivolumab

Indication for Nivolumab

Population group: only adults (18 years old or older)

Nivolumab as monotherapy is indicated for the treatment of recurrent or metastatic squamous cell cancer of the head and neck in adults progressing on or after platinum-based therapy.

For this indication, competent medicine agencies globally authorize below treatments:

240 mg every 2 weeks

Route of admnistration

Intravenous

Defined daily dose

240 mg

Dosage regimen

240 mg once every 14 day(s)

Detailed description

As monotherapy: 240 mg every 2 weeks.

Dosage considerations

Infusion time over 30 minutes.

Active ingredient

Nivolumab

Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody (HuMAb), which binds to the programmed death-1 (PD-1) receptor and blocks its interaction with PD-L1 and PD-L2. Nivolumab potentiates T-cell responses, including anti-tumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands. In syngeneic mouse models, blocking PD-1 activity resulted in decreased tumour growth.

Read more about Nivolumab

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