Anaphylaxis

Active Ingredient: Methylprednisolone

Indication for Methylprednisolone

Population group: only minors (0 - 18 years old)

For this indication, competent medicine agencies globally authorize below treatments:

10-30 mg/kg in 1-4 divided doses daily

Route of admnistration

Intramuscular

Defined daily dose

10 - 30 mg per kg of body weight

Dosage regimen

From 2.5 To 7.5 mg per kg of body weight 4 time(s) per day every day

Detailed description

In the treatment of high dose indications, such as haematological, rheumatic, renal and dermatological conditions, a dosage of 30 mg/kg/day to a maximum of 1 g/day is recommended. This dosage may be repeated for three pulses either daily or on alternate days. In the treatment of graft rejection reactions following transplantation, a dosage of 10 to 20 mg/kg/day for up to 3 days, to a maximum of 1 g/day, is recommended.

10-30 mg/kg in 1-4 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

10 - 30 mg per kg of body weight

Dosage regimen

From 2.5 To 7.5 mg per kg of body weight 4 time(s) per day every day

Detailed description

In the treatment of high dose indications, such as haematological, rheumatic, renal and dermatological conditions, a dosage of 30 mg/kg/day to a maximum of 1 g/day is recommended. This dosage may be repeated for three pulses either daily or on alternate days. In the treatment of graft rejection reactions following transplantation, a dosage of 10 to 20 mg/kg/day for up to 3 days, to a maximum of 1 g/day, is recommended.

Dosage considerations

When administering methylprednisolone in high doses intravenously it should be given over a period of at least 30 minutes. Doses up to 250 mg should be given intravenously over a period of at least five minutes.

For intravenous infusion the initially prepared solution may be diluted with 5% dextrose in water, isotonic saline solution, or 5% dextrose in isotonic saline solution. To avoid compatibility problems with other drugs methylprednisolone should be administered separately, only in the solutions mentioned.

Active ingredient

Methylprednisolone

Methylprednisolone is a synthetic glucocorticoid and a methyl derivative of prednisolone. Methylprednisolone is a potent anti-inflammatory agent with the capacity to profoundly inhibit the immune system.

Read more about Methylprednisolone

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