RADIOGENIX SYSTEM Technetium tc 99m generator injection Ref.[10398] Active ingredients: Technetium ⁹⁹ᵐTc pertechnetate

Chemical Characteristics

The RadioGenix System provides Sodium Pertechnetate Tc 99m Injection, USP for intravenous use, intravesicular use, ophthalmic use, or for preparing radiopharmaceutical kits. The RadioGenix System uses a non-uranium potassium molybdate Mo-99 source solution to produce Sodium Pertechnetate Tc 99m Injection, USP. The RadioGenix System uses potassium molybdate Mo-99 sources at an activity of 6 Ci/29 mL (222 GBq) at the date and time of calibration.

Elution of RadioGenix System produces Sodium Pertechnetate Tc-99m (Na99mTcO4) in approximately 5 mL of sterile 0.9% sodium chloride injection solution. The activity of Sodium Pertechnetate Tc-99m produced varies (30 mCi/mL to 1,153 mCi/mL of technetium Tc-99m) and depends on the activity of potassium molybdate Mo-99 present in the source container originally, the decay time since the calibration time, and the elapsed time since the previous Sodium Pertechnetate Tc-99m elution.

Sodium Pertechnetate Tc-99m is an inorganic compound with the formula Na99mTcO4. In solution, Sodium Pertechnetate exists as dissociated Na+ cations and pertechnetate TcO4-anions with the following molecular structure:

The eluted Sodium Pertechnetate Tc 99m Injection, USP is a sterile, non-pyrogenic, clear, and colorless solution. The pH of the solution is between 4.5 and 7.5.

Physical Characteristics

Technetium Tc-99m

Technetium Tc-99m decays by isomeric transition with a physical half-life of 6.01 hours. The principal photon that is useful for detection and imaging studies is shown in Table 8.

Table 8. Principal Radiation Emission Data technetium Tc-99m:

The air-kerma-rate (exposure-rate) constant for technetium Tc-99m is 5.23 m²·pGy·(MBq)-1·s-1 [0.795 cm²·R·(mCi)-1·h-1]. A range of values for the relative radiation attenuation by the various thicknesses of Pb is shown in Table 9. For example, the use of 3 mm thickness of Pb will attenuate the radiation exposure by a factor of about 1,000.

Table 9. Radiation Attenuation by Lead Shielding:

Molybdenum Mo-99

Molybdenum Mo-99 decays to technetium Tc-99m with a molybdenum Mo-99 half-life of 66 hours. This means that 77.7% of the activity remains after 24 hours; 60.4% remains after 48 hours, see Table 10.

Table 10. Molybdenum Mo-99 Decay Chart half-life 66.0 hours:

* calibration time

The physical decay characteristics of molybdenum Mo-99 are such that 88.6% of the decaying molybdenum Mo-99 atoms form Technetium Tc-99m. RadioGenix System elutions may be made at any time, but the amount of technetium Tc-99m available will depend on the time interval measured from the last elution cycle. Eluting the RadioGenix System every 24 hours will provide the maximal yield of Sodium Pertechnetate Tc-99m.

To correct for physical decay of technetium Tc-99m, the fractions that remain at selected intervals of time are shown in Table 11.

Table 11. Physical Decay Chart. Technetium Tc-99m, half-life 6.01 Hours:

* calibration time

RadioGenix System 1.2

Chemical Characteristics

The RadioGenix System provides Sodium Pertechnetate Tc 99m Injection, USP for intravenous use, intravesicular use, ophthalmic use, or for preparing radiopharmaceutical kits. The RadioGenix System uses a non-uranium potassium molybdate Mo-99 source solution to produce Sodium Pertechnetate Tc 99m Injection, USP. The RadioGenix System uses potassium molybdate Mo-99 sources at an activity of 6 Ci/29 mL (222 GBq) at the date and time of calibration.

Elution of RadioGenix System produces Sodium Pertechnetate Tc-99m (Na99mTcO4) in approximately 5 mL of sterile 0.9% sodium chloride injection solution. The activity of Sodium Pertechnetate Tc-99m produced varies (25 mCi/mL to 1,015 mCi/mL of technetium Tc-99m) and depends on the activity of potassium molybdate Mo-99 present in the source container originally, the decay time since the calibration time, and the elapsed time since the previous Sodium Pertechnetate Tc-99m elution.

Sodium Pertechnetate Tc-99m is an inorganic compound with the formula Na99mTcO4. In solution, Sodium Pertechnetate exists as dissociated Na+ cations and pertechnetate TcO4-anions with the following molecular structure:

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The eluted Sodium Pertechnetate Tc 99m Injection, USP is a sterile, non-pyrogenic, clear, and colorless solution. The pH of the solution is between 4.5 and 7.5.

Physical Characteristics

Technetium Tc-99m

Technetium Tc-99m decays by isomeric transition with a physical half-life of 6.01 hours. The principal photon that is useful for detection and imaging studies is shown in Table 8.

Table 8. Principal Radiation Emission Data technetium Tc-99m:

The air-kerma-rate (exposure-rate) constant for technetium Tc-99m is 5.23 m²·pGy·(MBq)-1·s-1 [0.795 cm²·R·(mCi)-1·h-1]. A range of values for the relative radiation attenuation by the various thicknesses of Pb is shown in Table 9. For example, the use of 3 mm thickness of Pb will attenuate the radiation exposure by a factor of about 1,000.

Table 9. Radiation Attenuation by Lead Shielding:

Molybdenum Mo-99

Molybdenum Mo-99 decays to technetium Tc-99m with a molybdenum Mo-99 half-life of 66 hours. This means that 77.7% of the activity remains after 24 hours; 60.4% remains after 48 hours, see Table 10.

Table 10. Molybdenum Mo-99 Decay Chart half- life 66.0 hours:

* calibration time

The physical decay characteristics of molybdenum Mo-99 are such that 88.6% of the decaying molybdenum Mo-99 atoms form Technetium Tc-99m. RadioGenix System elutions may be made at any time, but the amount of technetium Tc-99m available will depend on the time interval measured from the last elution cycle. Eluting the RadioGenix System every 24 hours will provide the maximal yield of Sodium Pertechnetate Tc-99m.

To correct for physical decay of technetium Tc-99m, the fractions that remain at selected intervals of time are shown in Table 11.

Table 11. Physical Decay Chart. Technetium Tc-99m, half-life6.01 Hours:

* calibration time