Source: FDA, National Drug Code (US) Revision Year: 2020
Tiazac (diltiazem hydrochloride) is a calcium ion cellular influx inhibitor (slow channel blocker). Chemically, diltiazem hydrochloride is 1,5-Benzothiazepin-4(5H)one, 3(acetyloxy)5[2-(dimethylamino)ethyl]-2, 3-dihydro-2-(4-methoxyphenyl),monohydrochloride, (+)cis-.
The chemical structure is:
Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol and chloroform and has a molecular weight of 450.98. Tiazac capsules contain diltiazem hydrochloride in extended-release beads at doses of 120, 180, 240, 300, 360 and 420 mg.
Tiazac also contains: black iron oxide, D&C Red No. 28, ethyl acrylate and methyl methacrylate copolymer dispersion, FD&C Blue No. 1, FD&C Green No. 3, FD&C Red No. 40, gelatin, hypromellose, magnesium stearate, microcrystalline cellulose, polysorbate, povidone, simethicone, sucrose stearate, talc, and titanium dioxide.
USP Drug Release Test 6
For oral administration.
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Tiazac (diltiazem hydrochloride) Extended-Release Capsules, USP
Distributed by: Bausch Health US, LLC, Bridgewater, NJ 08807 USA Manufactured by: Bausch Health Companies Inc., Steinbach, MB R5G 1Z7, Canada |
| Drug | Countries | |
|---|---|---|
| TIAZAC | Canada, United States |
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