Product Name and Form
Neurobion coated tablets.
White, shiny, round, biconvex coated tablet.
Qualitative and Quantitative Composition
One coated tablet contains:
Thiamine disulphide (vitamin B1): 100 mg
Pyridoxine hydrochloride (vitamin B6): 200 mg
Cyanocobalamin (vitamin B12): 200 μg
Excipients: Contains 40 mg lactose monohydrate and 133.22 mg sucrose.
For a complete list of excipients see section 6.1.
Thiamine pyrophosphate (TPP), the coenzymatic form of thiamine, is involved in two main types of metabolic reactions: decarboxylation of α-ketoacids (e.g. pyruvate, α-ketoglutarate and branched-chain keto acids) and transketolation (e.g. among hexose and pentose phosphates). Therefore, the principal physiological role of thiamine is as a coenzyme in carbohydrate metabolism, where TPP is required for several stages in the breakdown of glucose to provide energy.
Pyridoxine hydrochloride is Vitamin B6. It is converted to pyridoxal phosphate which is the co-enzyme for a variety of metabolic transformations. It is essential for human nutrition.
Hydroxocobalamin is used in the treatment and prevention of Vitamin B12 deficiency. For adults, the daily requirement of Vitamin B12 is probably about 1 to 2 micrograms and this amount is present in most normal diets. However, Vitamin B12 only occurs in animal products, not in vegetables, and therefore strict vegetarian or vegan diets that exclude dairy products may provide an inadequate amount, although a deficiency may not be apparent for many years.
Colloidal silicon dioxide
Titanium dioxide (E171)
Pack sizes and Marketing
Blister pack consisting of base film (hard PVC, transparent, coated with PVDC) and cover foil (aluminium foil coated with heat-sealing lacquer).
Package sizes: 20 coated tablets.
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