DIAMOX Tablet Ref.[6054] Active ingredients: Acetazolamide

Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2015 Publisher: Mercury Pharmaceuticals Ltd, Capital House, 85 King William Street, London EC4N 7BL, UK

Therapeutic indications

DIAMOX Tablets are for oral administration. Acteazolamide is an enzyme inhibitor which acts specifically on carbonic anhydrase. It is indicated in the treatment of:

Glaucoma: DIAMOX Tablets is useful in glaucoma (chronic simple (open angle) glaucoma, secondary glaucoma, and perioperatively in acute angle closure glaucoma where delay of surgery is desired in order to lower intraocular pressure) because it acts on inflow, decreasing the amount of aqueous secretion.
Abnormal retention of fluids: DIAMOX Tablets is a diuretic whose effect is due to the effect on the reversible hydration of carbon dioxide and dehydration of carbonic acid reaction in the kidney. The result is renal loss of HC0 3- ion which carries out sodium, water and potassium. DIAMOX Tablets can be used in conjunction with other diuretics when effects on several segments of the nepbron are desirable in the treatment of fluid retaining states.
Epilepsy: In conjunction with other anticonvulsants best results with DIAMOX Tablets have been seen in petit mal in children. Good results, however, have been seen in patients, both children and adults, with other types of seizures such as grand mal, mixed seizure patterns, myoclonic jerk patterns etc.

Posology and method of administration

Glaucoma (simple acute congestive and secondary)

Adults: 250-1,000mg (1-4 tablets) per 24 hours, usually in divided doses for amounts over 250mg daily.

Abnormal retention of fluid: Congestive heart failure, drug-induced oedema.

Adults: For diuresis, the starting dose is usually 250-375mg (1-1½ tablets) once daily in the morning. If, after an initial response, the patient fails to continue to lose oedema fluid, do not increase the dose but allow for kidney recovery by omitting a day. Best results are often obtained on a regime of 250-375mg (1-1½ tablets) daily for two days, rest a day, and repeat, or merely giving the DIAMOX tablets every other day. The use of DIAMOX tablets does not eliminate the need for other therapy, eg. digitalis, bed rest and salt restriction in congestive heart failure and proper supplementation with elements such as potassium in drug-induced oedema.

For cases of fluid retention associated with pre-menstrual tension, a daily dose (single) of 125-375mg is suggested.

Epilepsy

Adults: 250-1,000mg daily in divided doses.

Children: 8-30mg/kg in daily divided doses and not to exceed 750mg/day. The change from other medication to DIAMOX tablets should be gradual.

Elderly: DIAMOX tablets should only be used with particular caution in elderly patients or those with potential obstruction in the urinary tract or with disorders rendering their electrolyte balance precarious or with liver dysfunction.

Overdose

No specific antidote. Supportive measures with correction of electrolyte and fluid balance. Force fluids.

Shelf life

48 months.

Special precautions for storage

Do not store above 25°C. Store in the original pack in order to protect from light and moisture.

Nature and contents of container

Amber glass bottles with metal screw-on caps.

Polypropylene bottles with plastic screw-on caps.

The product is supplied in bottles of 112 tablets.

Special precautions for disposal and other handling

None.

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