DIAMOX Sodium Powder for solution for injection Ref.[6055] Active ingredients: Acetazolamide

Routes of Administration

Intravenous or intramuscular injection. The direct intravenous route is preferred as intramuscular use is limited by the alkaline pH of the solution.

Glaucoma (simple acute congestive and secondary)

Adults: 250-1000mg per 24 hours, usually in divided doses for amounts over 250mg daily.

Abnormal retention of fluid: Congestive heart-failure, drug-induced oedema.

Adults: For diuresis, the starting dose is usually 250-375mg once daily in the morning. If, after an initial response, the patient fails to continue to lose oedema fluid, do not increase the dose but allow for kidney recovery by omitting a day.

Best results are often obtained on a regime of 250-375mg daily for two days, rest a day, and repeat or merely giving DIAMOX injection every other day. The use of DIAMOX injection does not eliminate the need for other therapy, e.g. digitalis, bed rest and salt restriction in congestive heart failure and proper supplementation with elements such as potassium in drug-induced oedema.

For cases of fluid retention associated with pre-menstrual tension, a daily dose (single) of 125-375mg is suggested.

Epilepsy

Adults: 250-1000mg daily in divided doses.

Children: 8-30mg/kg in daily divided doses and not to exceed 750mg/day.

The change from other medication to DIAMOX injection should be gradual.

Elderly: DIAMOX injection should only be used with particular caution in elderly patients or those with potential obstruction in the urinary tract or with disorders rendering their electrolyte balance precarious or with liver dysfunction.

For reconstitution please refer to section to section 6.6 below.

No specific antidote. Supportive measures with correction of electrolyte and fluid balance. Force fluids.

24 months.

Do not store above 25°C.

Glass vial with butyl rubber plug and aluminium ring seal.

Pack size 500mg vial.

Reconstitute each vial of DIAMOX Injection with at least 5ml of water for injection prior to use. The reconstituted solution is clear and colourless and does not contain an antimicrobial preservative. Any unused solution can be stored in a refrigerator for up to 24 hours but any solution not used within this period must be discarded.

The direct intravenous route of administration is preferred. Intramuscular injection may be employed but is painful due to the alkaline pH of the solution.