Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2015 Publisher: Chemidex Pharma Ltd, T/A Essential Generics or Chemidex Pharma, Chemidex House, Egham Business Village, Crabtree Road, Egham, Surrey, TW20 8RB, United Kingdom
Ampicillin is a broad-spectrum penicillin, indicated for the treatment of a wide range of bacterial infections caused by ampicillin-sensitive organisms. Typical indications include: ear, nose and throat infections, bronchitis, pneumonia, urinary tract infections, gonorrhoea, gynaecological infections, septicaemia, peritonitis, endocarditis, meningitis, enteric fever, gastro-intestinal infections.
Parenteral usage is indicated where oral dosage is inappropriate.
Ear, nose and throat infections: 250mg four times a day.
Bronchitis:
Routine therapy: 250mg four times a day.
High-dosage therapy: 1 g four times a day.
Pneumonia: 500 mg four times a day.
Urinary tract infections: 500 mg three times a day.
Gonorrhoea: 2 g orally with 1 g probenecid as a single dose. Repeated doses are recommended for the treatment of females.
Gastro-intestinal infections: 500-750 mg three to four times daily.
Enteric:
Acute: 1-2 g four times a day for two weeks.
Carriers: 1-2 g four times a day for four to twelve weeks.
Half adult routine dosage.
All recommended dosages are a guide only. In severe infections the above dosages may be increased, or ampicillin given by injection. Oral doses of ampicillin should be taken half to one hour before meals.
In the presence of severe renal impairment (creatinine clearance <10ml/min) a reduction in dose or extension of dose interval should be considered. In cases of dialysis, an additional dose should be administered after the procedure.
Gastrointestinal effects such as nausea, vomiting and diarrhoea may be evident and should be treated symptomatically.
Ampicillin may be removed from the circulation by haemodialysis.
Blister packs: five years.
Others: three years.
Containers: Do not store above 25°C. Keep the container tightly closed.
Blisters: Do not store above 25°C. Store in the original package.
Aluminium canister.
Glass bottle fitted with a screw cap.
Polypropylene tube with a polyethylene closure.
Aluminium foil pack – 4, 16, 50, 100, 500
Aluminium/PVC tray foil blister pack – 28
Aluminium/PVC/PVdC blister pack – 28
None.
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