TIOGUANINE Tablet Ref.[9069] Active ingredients: Tioguanine

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2017  Publisher: Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland

Product name and form

Tioguanine 40 mg Tablets.

Pharmaceutical Form

Tioguanine 40 mg Tablets are white to off-white tablet, round, biconvex scored and imprinting ‘T40’ on upper side, without score and debossing on lower side.

The scoreline is only to facilitate breaking for ease of swallowing and not to divide into equal doses.

Qualitative and quantitative composition

40 mg tioguanine BP per tablet.

Excipients: This product contains lactose.

For the full list of excipients, see section 6.1.

Active Ingredient Description
Tioguanine

Tioguanine is a sulphydryl analogue of guanine and behaves as a purine antimetabolite. It is activated to its nucleotide, thioguanylic acid. Tioguanine metabolites inhibit de novo purine synthesis and purine nucleotide interconversions. Tioguanine is also incorporated into nucleic acids and DNA (deoxyribonucleic acid) incorporation is claimed to contribute to the agent’s cytotoxicity.

List of Excipients

Lactose monohydrate NF
Starch, potato HSE
Acacia NF
Stearic acid NF
Magnesium stearate NF
Purified water USP

Pack sizes and marketing

Amber glass bottles with child-resistant polyethylene/polypropylene closures.

Pack size 25.

Marketing authorization holder

Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland

Marketing authorization dates and numbers

PL 39699/ 0045

29 October 1997/1 December 2008

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