Source: FDA, National Drug Code (US) Revision Year: 2020
Voxelotor is a hemoglobin S polymerization inhibitor.
The chemical name of voxelotor is: 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde.
Voxelotor has a molecular formula of C19H19N3O3 and a molecular weight of 337.4.
The chemical structure of voxelotor is:
Voxelotor, the active drug substance, is a white-to-yellow-to-beige compound in crystalline Form II of its free base. It is non-hygroscopic. It is highly soluble in common organic solvents such as acetone and toluene and insoluble in water (approximately 0.03 mg/mL).
Each OXBRYTA film-coated tablet for oral use contains 500 mg of voxelotor with the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate. In addition, the film coating contains: polyethylene glycol 3350, polyvinyl alcohol, talc, titanium dioxide, and yellow iron oxide.
| Dosage Forms and Strengths |
|---|
|
Tablets: 500 mg light yellow to yellow, oval shaped, biconvex, debossed with “GBT 500” on one side. |
| How Supplied |
|---|
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The 500 mg tablet is film-coated, light yellow to yellow, oval shaped, biconvex, debossed with “GBT 500” on one side, and available in:
The bottle also contains one desiccant canister and one polyester coil. Do not eat. |
| Drug | Countries | |
|---|---|---|
| OXBRYTA | Austria, Estonia, France, Croatia, Ireland, Italy, Lithuania, Poland, United States |
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