Betamethasone

Chemical formula: C₂₂H₂₉FO₅  Molecular mass: 392.461 g/mol  PubChem compound: 9782

Active ingredient description

Betamethasone is a glucocorticoid which is about eight to ten times as active as prednisolone on a weight-for-weight basis. Betamethasone has anti-inflammatory, antipruritic, and vasoconstrictive properties.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
A07EA04 Betamethasone A Alimentary tract and metabolism → A07 Antidiarrheals, intestinal antiinflammatory/antiinfective agents → A07E Intestinal antiinflammatory agents → A07EA Corticosteroids acting locally
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C05AA05 Betamethasone C Cardiovascular system → C05 Vasoprotectives → C05A Agents for treatment of hemorrhoids and anal fissures for topical use → C05AA Corticosteroids
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D07AC01 Betamethasone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07A Corticosteroids, plain → D07AC Corticosteroids, potent (group III)
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D07XC01 Betamethasone D Dermatologicals → D07 Corticosteroids, dermatological preparations → D07X Corticosteroids, other combinations → D07XC Corticosteroids, potent, other combinations
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H02AB01 Betamethasone H Systemic hormonal preparations, excl. Sex hormones and insulins → H02 Corticosteroids for systemic use → H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN → H02AB Glucocorticoids
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R01AD06 Betamethasone R Respiratory system → R01 Nasal preparations → R01A Decongestants and other nasal preparations for topical use → R01AD Corticosteroids
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R03BA04 Betamethasone R Respiratory system → R03 Drugs for obstructive airway diseases → R03B Other drugs for obstructive airway diseases, inhalants → R03BA Glucocorticoids
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S01BA06 Betamethasone S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain
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S01CB04 Betamethasone S Sensory organs → S01 Ophthalmologicals → S01C Antiinflammatory agents and antiinfectives in combination → S01CB Corticosteroids/antiinfectives/mydriatics in combination
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S02BA07 Betamethasone S Sensory organs → S02 Otologicals → S02B Corticosteroids → S02BA Corticosteroids
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S03BA03 Betamethasone S Sensory organs → S03 Ophthalmological and otological preparations → S03B Corticosteroids → S03BA Corticosteroids
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Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
Betnovate Cream Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
BETNOVATE Lotion Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
DIPROLENE AF Cream FDA, National Drug Code (US) MPI, US: SPL/PLR
BETNESOL Solution for injection Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

3D molecular structure

3D representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 378-44-9
DrugBank Drug: DB00443
KEGG Drug: D00244
PubChem Compound: 9782
RxNorm Ingredient: 1514
SNOMED-CT Concept: 116571008
Betamethasone (substance)
UNII Identifier: 9842X06Q6M
BETAMETHASONE

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