Estradiol Other names: Oestradiol

Chemical formula: C₁₈H₂₄O₂  Molecular mass: 272.382 g/mol  PubChem compound: 5757

Active ingredient description

Estradiol, is chemically and biologically identical to endogenous human estradiol. It substitutes for the loss of oestrogen production in menopausal women, and alleviates menopausal symptoms. Oestrogens prevent bone loss following menopause or ovariectomy.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
G03CA03 Estradiol G Genito urinary system and sex hormones → G03 Sex hormones and modulators of the genital system → G03C Estrogens → G03CA Natural and semisynthetic estrogens, plain
Discover more medicines within G03CA03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ESTRING Vaginal delivery system Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ZUMENON Film-coated tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ESTRADOT Transdermal patch Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ESTRACE Cream FDA, National Drug Code (US) MPI, US: SPL/Old
ESTRACE Tablet FDA, National Drug Code (US) MPI, US: SPL/Old
CLIMARA Patch FDA, National Drug Code (US) MPI, US: SPL/PLR
VAGIRUX Vaginal tablet Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ESTROGEL Gel FDA, National Drug Code (US) MPI, US: SPL/PLR
DIVIGEL Gel FDA, National Drug Code (US) MPI, US: SPL/PLR

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 50-28-2
CAS Substance: 979-32-8
DrugBank Drug: DB00783
KEGG Drug: D00105
PubChem Compound: 5757
RxNorm Ingredient: 4083
SNOMED-CT Concept: 126172005
Estradiol (substance)
SNOMED-CT Concept: 76780005
Estradiol (substance)
UNII Identifier: 4TI98Z838E
ESTRADIOL

Medicines

Estradiol is an active ingredient of these brands:

United States (US)

Australia (AU)

Austria (AT)

Brazil (BR)

Canada (CA)

Croatia (HR)

Cyprus (CY)

  • VAGIFEM as ESTRADIOL HEMIHYDRATE

  • (combination) ANGELIQ as ESTRADIOL HEMIHYDRATE
  • (combination) CYCLACUR as ESTRADIOL VALERATE
  • (combination) FEMOSTON as ESTRADIOL HEMIHYDRATE
  • (combination) QLAIRA as ESTRADIOL VALERATE
  • (combination) TRISEQUENS as ESTRADIOL HEMIHYDRATE
  • (combination) ZOELY

Ecuador (EC)

  • ESTROGEL
  • LENZETTO as ESTRADIOL HEMIHYDRATE
  • LINDISC

  • (combination) ANGELIQ as ESTRADIOL HEMIHYDRATE
  • (combination) AVADEN
  • (combination) CLIMENE as ESTRADIOL VALERATE
  • (combination) CYCLOFEMINA as ESTRADIOL CYPIONATE
  • (combination) FEMALVI as ESTRADIOL HEMIHYDRATE
  • (combination) FEMGYL as ESTRADIOL VALERATE
  • (combination) FEMIDEN as ESTRADIOL HEMIHYDRATE
  • (combination) FEMVULEN as ESTRADIOL ENANTHATE
  • (combination) GADOFEM as ESTRADIOL HEMIHYDRATE
  • (combination) GYNESTROL as ESTRADIOL VALERATE
  • (combination) GYNODIAN DEPOT as ESTRADIOL VALERATE
  • (combination) MARCELLE
  • (combination) MESIGYNA as ESTRADIOL VALERATE
  • (combination) MESQUIL as ESTRADIOL VALERATE
  • (combination) MESYGEST as ESTRADIOL VALERATE
  • (combination) MIRANDA as ESTRADIOL HEMIHYDRATE
  • (combination) NOFERTYL as ESTRADIOL VALERATE
  • (combination) NOMAGEST as ESTRADIOL ENANTHATE
  • (combination) PROGYLUTON as ESTRADIOL VALERATE
  • (combination) PROTER as ESTRADIOL ENANTHATE
  • (combination) QLAIRA as ESTRADIOL VALERATE
  • (combination) RUBI as ESTRADIOL VALERATE
  • (combination) SOLUNA as ESTRADIOL VALERATE
  • (combination) SYNOVULAR as ESTRADIOL ENANTHATE
  • (combination) VELBIENNE as ESTRADIOL VALERATE

Estonia (EE)

Finland (FI)

France (FR)

Germany (DE)

Hong Kong (HK)

Ireland (IE)

Israel (IL)

Italy (IT)

Japan (JP)

Lithuania (LT)

Malta (MT)

Mexico (MX)

Netherlands (NL)

New Zealand (NZ)

Poland (PL)

Romania (RO)

Singapore (SG)

South Africa (ZA)

Spain (ES)

Tunisia (TN)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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