Loteprednol

Chemical formula: C₂₄H₃₁ClO₇  Molecular mass: 394.889 g/mol 

Active ingredient description

Loteprednol etabonate is a new class of corticosteroid with potent antiinflammatory activity designed to be active at the site of action. Its antiinflammatory activity is similar to the most powerful steroid used in ophthalmology but with less intraocular pressure.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
S01BA14 Loteprednol S Sensory organs → S01 Ophthalmologicals → S01B Antiinflammatory agents → S01BA Corticosteroids, plain
Discover more medicines within S01BA14

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LOTEMAX Eye-drops, suspension Medicines & Healthcare Products Regulatory Agency (GB) MPI, EU: SmPC
ALREX Ophthalmic suspension FDA, National Drug Code (US) MPI, US: SPL/Old

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 129260-79-3
DrugBank Drug: DB00873
RxNorm Ingredient: 237027
SNOMED-CT Concept: 419711001
Loteprednol (substance)
UNII Identifier: Z8CBU6KR16
LOTEPREDNOL

Medicines

Loteprednol is an active ingredient of these brands:

United States (US)

  • ALREX as LOTEPREDNOL ETABONATE
  • INVELTYS as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

  • (combination) ZYLET as LOTEPREDNOL ETABONATE

Austria (AT)

Brazil (BR)

  • ALREX as LOTEPREDNOL ETABONATE
  • LOTEPROL as LOTEPREDNOL ETABONATE

  • (combination) ZYLET as LOTEPREDNOL ETABONATE

Canada (CA)

  • ALREX as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

Cyprus (CY)

Ecuador (EC)

Estonia (EE)

Hong Kong (HK)

  • ALREX as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

Ireland (IE)

Israel (IL)

  • LOTEMAX as LOTEPREDNOL ETABONATE

  • (combination) ZYLET as LOTEPREDNOL ETABONATE

Lithuania (LT)

Mexico (MX)

Poland (PL)

Singapore (SG)

  • ALREX as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

  • (combination) ZYLET as LOTEPREDNOL ETABONATE

South Africa (ZA)

  • ALREX as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

Tunisia (TN)

Turkey (TR)

  • DOLTE as LOTEPREDNOL ETABONATE
  • LOTEFORTE as LOTEPREDNOL ETABONATE
  • LOTEMAX as LOTEPREDNOL ETABONATE

  • (combination) LOTEBRA as LOTEPREDNOL ETABONATE
  • (combination) TOBRALOT as LOTEPREDNOL ETABONATE
  • (combination) ZYLET as LOTEPREDNOL ETABONATE
  • (combination) ZYLOTRA as LOTEPREDNOL ETABONATE

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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