Pentosan polysulfate

Chemical formula: C₁₀H₁₈O₂₁S₄  Molecular mass: 602.497 g/mol  PubChem compound: 37720

Active ingredient description

The hypothetic mechanism of action of pentosan polysulfate includes a local effect in the bladder after systemic administration and excretion into the urine by binding of glycosaminoglycans to the deficient mucous of the bladder. It is hypothesized, that a potential barrier function of pentosan polysulfate instead of the damaged urothelial mucus might play a role as well the antiinflammatory activity of pentosan polysulfate sodium.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
C05BA04 Pentosan polysulfate sodium C Cardiovascular system → C05 Vasoprotectives → C05B Antivaricose therapy → C05BA Heparins or heparinoids for topical use
Discover more medicines within C05BA04
G04BX15 Pentosan polysulfate sodium G Genito urinary system and sex hormones → G04 Urologicals → G04B Other urologicals, incl. antispasmodics → G04BX Other urologicals
Discover more medicines within G04BX15

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ELMIRON Hard capsule European Medicines Agency (EU) MPI, EU: SmPC

External identifiers

CAS Substance: 140207-93-8
DrugBank Drug: DB00686
PubChem Compound: 37720
SNOMED-CT Concept: 109117004
Pentosan polysulfate sodium (substance)
UNII Identifier: 914032762Y
PENTOSAN POLYSULFATE SODIUM

Medicines

Pentosan polysulfate is an active ingredient of these brands:

United States (US)

Austria (AT)

Canada (CA)

Croatia (HR)

Estonia (EE)

France (FR)

Hong Kong (HK)

  • (combination) ANSO

Ireland (IE)

Italy (IT)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Spain (ES)

Turkey (TR)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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