Voclosporin

Chemical formula: C₆₃H₁₁₁N₁₁O₁₂  Molecular mass: 1,214.646 g/mol  PubChem compound: 6918486

Active ingredient description

Voclosporin is a calcineurin-inhibitor immunosuppressant that inhibits calcineurin in a dose-dependent manner. The immunosuppressant activity results in inhibition of lymphocyte proliferation, T-cell cytokine production, and expression of T-cell activation surface antigens.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
L04AD03 L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AD Calcineurin inhibitors
Discover more medicines within L04AD03

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
LUPKYNIS Soft capsule European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 515814-01-4
DrugBank Drug: DB11693
KEGG Drug: D09033
PubChem Compound: 6918486
RxNorm Ingredient: 2475166
SNOMED-CT Concept: 1149151008
Voclosporin (substance)
UNII Identifier: 2PN063X6B1
VOCLOSPORIN

Medicines

Voclosporin is an active ingredient of these brands:

United States (US)

Austria (AT)

Croatia (HR)

Cyprus (CY)

Estonia (EE)

Finland (FI)

France (FR)

Ireland (IE)

Italy (IT)

Lithuania (LT)

Romania (RO)

Spain (ES)

United Kingdom (UK)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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