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AERRANE

Found in: Spain France Singapore United Kingdom

Active Ingredients

#
Chemical substance
Description
1
Isoflurane

Isoflurane is a general inhalational anaesthetic for use in induction and maintenance. Isoflurane provides rapid induction of anaesthesia and also rapid recovery.

Isoflurane is a fluorinated ether with general anesthetic and muscle relaxant activities. Although the exact mechanism of action has not been established, inhaled isoflurane, appears to act on the lipid matrix of the neuronal cell membrane, which results in disruption of neuronal transmission. This agent enhances the release of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), thereby increasing the activity of the inhibitory neurotransmitter on synaptic transmission. Isoflurane may also both inhibit glutamatergic excitatory transmission by increasing glutamate re-uptake, and potentiate glycine receptor activity, which decreases motor function. In addition, isoflurane may alter certain pro- and anti-inflammatory cytokines, including interleukin-6 and -10 (IL-6, IL-10), possibly through the activation of the nuclear factor kappa B (NF-KB) pathway, which may affect immune responses during surgery.

ATC Classification

Code
Title
Category
N01AB06
Isoflurane
N Nervous system → N01 Anesthetics → N01A Anesthetics, general → N01AB Halogenated hydrocarbons

Product Monographs

Monograph
Type
Country
AERRANE Liquid for inhalation
MPI, EU: SmPC
UK

Identifiers

Authority
Identifier(s)
Health Sciences Authority (SG)
Identifier(s): 08670P
Base de données publique des médicaments (FR)
Identifier(s): 63498500
Centro de información online de medicamentos de la AEMPS (ES)
Identifier(s): 60378