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AFSTYLA

Found in: Austria Cyprus Spain France Netherlands Singapore

Active Ingredients

#
Chemical substance
Description
1
Lonoctocog alfa

Lonoctocog alfa is a recombinant human protein that replaces the missing coagulation factor VIII needed for effective hemostasis. Lonoctocog alfa is a single polypeptide chain with a truncated B-domain that allows for a covalent bridge to link the factor VIII heavy and light chains. Lonoctocog alfa has demonstrated a higher VWF affinity relative to full-length rFVIII. VWF stabilizes factor VIII and protects it from degradation. Activated lonoctocog alfa has an amino acid sequence identical to endogenous FVIIIa.

ATC Classification

Code
Title
Category
B02BD02
Coagulation factor VIII
B Blood and blood forming organs → B02 Antihemorrhagics → B02B Vitamin K and other hemostatics → B02BD Blood coagulation factors

Product Monographs

Monograph
Type
Country
AFSTYLA Powder and solvent for solution for injection
MPI, EU: SmPC

Identifiers

Authority
Identifier(s)
Health Sciences Authority (SG)
Identifier(s): 15820P, 15821P, 15822P, 15823P, 15824P
Z-Index G-Standaard PRK (NL)
Identifier(s): 139254, 139262, 139270, 139289, 139297, 139300, 139319
Base de données publique des médicaments (FR)
Identifier(s): 60944716, 61411315, 61906519, 64280351, 64477690, 66216027, 67710662
Centro de información online de medicamentos de la AEMPS (ES)
Identifier(s): 1161158001, 1161158002, 1161158003, 1161158005