ALIMTA

This brand name is authorized in Austria, Brazil, Canada, Cyprus, Ecuador, Estonia, Spain, Finland, France, Hong Kong, Ireland, Israel, Japan, Lithuania, Mexico, Netherlands, New Zealand, Poland, Romania, Singapore, Tunisia, Turkey, United Kingdom, United States, South Africa

Active ingredients

The drug ALIMTA contains one active pharmaceutical ingredient (API):

1 Pemetrexed
UNII 9T47E4OM16 - PEMETREXED DISODIUM HEPTAHYDRATE

Pemetrexed is a folate analog metabolic inhibitor that exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT) and and to a lesser extent aminoimidazole carboxamide ribonucleotide formyltransferase (AICARFT), which are folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Pemetrexed is taken into cells by membrane carriers such as the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, pemetrexed is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, is thought to occur to a lesser extent, in normal tissues. Polyglutamated metabolites are thought to have an increased intracellular half-life resulting in prolonged drug action in malignant cells.

Read about Pemetrexed

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01BA04 Pemetrexed L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BA Folic acid analogues
Discover more medicines within L01BA04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: BR Câmara de Regulação do Mercado de Medicamentos Identifier(s): 507603401154210, 507603402150219
Country: CA Health Products and Food Branch Identifier(s): 02253437, 02306433
Country: EC Agencia Nacional de Regulación, Control y Vigilancia Sanitaria Identifier(s): 29014-09-09, 6201-MEE-0421
Country: EE Ravimiamet Identifier(s): 1187849, 1362529
Country: ES Centro de información online de medicamentos de la AEMPS Identifier(s): 04290001, 04290002
Country: FI Lääkealan turvallisuus- ja kehittämiskeskus Identifier(s): 019797, 120062
Country: FR Base de données publique des médicaments Identifier(s): 67323808, 67713231
Country: GB Medicines & Healthcare Products Regulatory Agency Identifier(s): 146759, 89935
Country: HK Department of Health Drug Office Identifier(s): 53331, 58016
Country: IL מִשְׂרַד הַבְּרִיאוּת Identifier(s): 7336
Country: JP 医薬品医療機器総合機構 Identifier(s): 4229401D1020, 4229401D2026
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1027355, 1050849
Country: MX Comisión Federal para la Protección contra Riesgos Sanitarios Identifier(s): 125M2005
Country: NL Z-Index G-Standaard, PRK Identifier(s): 138061, 138088
Country: NZ Medicines and Medical Devices Safety Authority Identifier(s): 11451, 13307
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100100780, 100104794
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W42003001, W52526001
Country: SG Health Sciences Authority Identifier(s): 13042P, 13480P
Country: TN Direction de la Pharmacie et du Médicament Identifier(s): 4323032H
Country: TR İlaç ve Tıbbi Cihaz Kurumu Identifier(s): 8699673261133, 8699673261140
Country: US FDA, National Drug Code Identifier(s): 0002-7623, 0002-7640
Country: ZA Health Products Regulatory Authority Identifier(s): 42/26/0448, A39/26/0028

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