AYVAKYT

This brand name is authorized in Austria, Estonia, France, Ireland, Lithuania, Poland, Romania, United Kingdom

Active ingredients

The drug AYVAKYT contains one active pharmaceutical ingredient (API):

1 Avapritinib
UNII 513P80B4YJ - AVAPRITINIB

Avapritinib is a tyrosine kinase inhibitor that targets PDGFRA and PDGFRA D842 mutants as well as multiple KIT exon 11, 11/17 and 17 mutants with half maximal inhibitory concentrations (IC50s) less than 25 nM. Certain mutations in PDGFRA and KIT can result in the autophosphorylation and constitutive activation of these receptors which can contribute to tumor cell proliferation. Other potential targets for avapritinib include wild type KIT, PDGFRB, and CSFR1.

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
AYVAKYT Film-coated tablet European Medicines Agency (EU) MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01EX18 L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors
Discover more medicines within L01EX18

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: EE Ravimiamet Identifier(s): 1828201, 1828212, 1828223, 1878509, 1878510
Country: FR Base de données publique des médicaments Identifier(s): 63189920, 64069767, 65304816
Country: GB Medicines & Healthcare Products Regulatory Agency Identifier(s): 390640, 390643, 390648
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1091244, 1091245, 1091246
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100441847, 100441853, 100441860
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W69470001, W69471001, W69472001, W69473001, W69474001

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