CIAMBRA

This brand name is authorized in Austria, Estonia, Croatia, Ireland, Lithuania, Poland, Romania

Active ingredients

The drug CIAMBRA contains one active pharmaceutical ingredient (API):

1 Pemetrexed
UNII 2PKU919BA9 - PEMETREXED DISODIUM

Pemetrexed is a folate analog metabolic inhibitor that exerts its action by disrupting folate-dependent metabolic processes essential for cell replication. In vitro studies have shown that pemetrexed inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyltransferase (GARFT) and and to a lesser extent aminoimidazole carboxamide ribonucleotide formyltransferase (AICARFT), which are folate-dependent enzymes involved in the de novo biosynthesis of thymidine and purine nucleotides. Pemetrexed is taken into cells by membrane carriers such as the reduced folate carrier and membrane folate binding protein transport systems. Once in the cell, pemetrexed is converted to polyglutamate forms by the enzyme folylpolyglutamate synthetase. The polyglutamate forms are retained in cells and are inhibitors of TS and GARFT. Polyglutamation is a time- and concentration-dependent process that occurs in tumor cells and, is thought to occur to a lesser extent, in normal tissues. Polyglutamated metabolites are thought to have an increased intracellular half-life resulting in prolonged drug action in malignant cells.

Read about Pemetrexed

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
CIAMBRA Powder for concentrate for solution for infusion European Medicines Agency (EU) MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01BA04 Pemetrexed L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BA Folic acid analogues
Discover more medicines within L01BA04

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: EE Ravimiamet Identifier(s): 1706138, 1706149
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1079095, 1079096
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100358112, 100358129
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W63201001

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