This brand name is authorized in Canada, United States
The drug INQOVI contains a combination of these active pharmaceutical ingredients (APIs):
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1
Decitabine
UNII 776B62CQ27 - DECITABINE
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Decitabine is a cytidine deoxynucleoside analogue that selectively inhibits DNA methyltransferases at low doses, resulting in gene promoter hypomethylation that can result in reactivation of tumour suppressor genes, induction of cellular differentiation or cellular senescence followed by programmed cell death. |
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2
Cedazuridine
UNII 39IS23Q1EW - CEDAZURIDINE
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Cedazuridine inhibits cytidine deaminase (CDA), an enzyme that is responsible for the degradation of cytidine nucleosides, including the cytidine analog decitabine. Oral administration of cedazuridine with decitabine increases the systemic exposure of decitabine via inhibition of first pass metabolism of decitabine in the gut and liver by CDA. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| INQOVI Film-coated tablet | FDA, National Drug Code (US) | MPI, US: SPL/PLR |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BC58 | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BC Pyrimidine analogues | |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: CA | Health Products and Food Branch | Identifier(s): 02501600 |
| Country: US | FDA, National Drug Code | Identifier(s): 64842-0727 |
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