KEVZARA

This brand name is authorized in Austria, Canada, Estonia, Spain, Finland, France, Hong Kong, Croatia, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Singapore, United Kingdom, United States

Active ingredients

The drug KEVZARA contains one active pharmaceutical ingredient (API):

1 Sarilumab UNII NU90V55F8I - SARILUMAB

Sarilumab is a human monoclonal antibody (IgG1 subtype) that specifically binds to both soluble and membrane-bound IL-6 receptors (IL-6Rα), and inhibits IL-6-mediated signalling which involves ubiquitous signal-transducing glycoprotein 130 (gp130) and the Signal Transducer and Activator of Transcription-3 (STAT-3). In functional human cell-based assays, sarilumab was able to block the IL-6 signalling pathway, measured as STAT-3 inhibition, only in the presence of IL-6. Read about Sarilumab

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
KEVZARA Solution for injection	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L04AC14		L Antineoplastic and immunomodulating agents → L04 Immunosuppressants → L04A Immunosuppressants → L04AC Interleukin inhibitors
Discover more medicines within L04AC14

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: CA	Health Products and Food Branch	Identifier(s): 02460521, 02460548, 02472961, 02472988
Country: EE	Ravimiamet	Identifier(s): 1748583, 1748594, 1748606, 1748617, 1748628, 1748639, 1748640, 1748651, 1786945, 1786956, 1786967, 1786978
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 1171196003, 1171196005, 1171196007
Country: FI	Lääkealan turvallisuus- ja kehittämiskeskus	Identifier(s): 479260, 545229, 576613
Country: FR	Base de données publique des médicaments	Identifier(s): 61709735, 63820638, 64326560, 69240179
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 347354, 347357, 347360, 347363
Country: HK	Department of Health Drug Office	Identifier(s): 65726, 65727
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8118, 8119
Country: IT	Agenzia del Farmaco	Identifier(s): 045491014, 045491026, 045491038, 045491040, 045491053, 045491065, 045491077, 045491089, 045491091, 045491103, 045491115, 045491127
Country: JP	医薬品医療機器総合機構	Identifier(s): 3999444G1022, 3999444G2029, 3999444G3025, 3999444G4021
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1083200, 1083201, 1083202, 1083203, 1083204, 1083205, 1083206, 1083207, 1084576, 1084577, 1084578, 1084579
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 144177, 144185, 144215, 144223
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100390593, 100390601, 100390618, 100390624
Country: SG	Health Sciences Authority	Identifier(s): 15681P, 15682P, 15737P, 15738P
Country: US	FDA, National Drug Code	Identifier(s): 0024-5908, 0024-5910, 0024-5920, 0024-5922