NUSSIDEX

This brand name is authorized in Israel

Active ingredients

The drug NUSSIDEX contains a combination of these active pharmaceutical ingredients (APIs):

1 Dexchlorpheniramine
UNII B10YD955QW - DEXCHLORPHENIRAMINE MALEATE

Dexchlorpheniramine, the d-isomer of the racemic compound chlorpheniramine, is two times more active than chlorpheniramine. Dexchlorpheniramine does not prevent the release of histamine, but rather, competes with free histamine for binding at the H1-receptor sites, and competitively antagonizes the effects of histamine on H1-receptors in the GI tract, uterus, large blood vessels, and bronchial muscle. Blockade of H1-receptors also suppresses the formation of oedema, flare, and pruritus that result from histaminic activity. Since dexchlorpheniramine binds to central and peripheral H1-receptors, sedative effects are likely to occur. Dexchlorpheniramine has high antihistaminic activity, moderate anticholinergic effects and minimal sedative effects.

Read about Dexchlorpheniramine
2 Pseudoephedrine
UNII 6V9V2RYJ8N - PSEUDOEPHEDRINE HYDROCHLORIDE

Pseudoephedrine is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. It has alpha and beta adrenergic activity and some stimulant effect on the central nervous system. The sympathomimetic effect of pseudoephedrine produces vasoconstriction which in turn relieves nasal congestion.

Read about Pseudoephedrine

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: IL מִשְׂרַד הַבְּרִיאוּת Identifier(s): 1620, 1622

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