ONPATTRO

This brand name is authorized in Austria, Brazil, Canada, Cyprus, Estonia, Spain, France, Croatia, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Romania, United Kingdom, United States

Active ingredients

The drug ONPATTRO contains one active pharmaceutical ingredient (API):

1 Patisiran UNII WO0YM16LKG - PATISIRAN SODIUM

Patisiran is a double-stranded small interfering ribonucleic acid (siRNA) that specifically targets a genetically conserved sequence in the 3’ untranslated region of all mutant and wild-type TTR mRNA. Through a natural process called RNA interference (RNAi), patisiran causes the catalytic degradation of TTR mRNA in the liver, resulting in a reduction of serum TTR protein, a carrier of retinol binding protein which facilitates transport of vitamin A in the blood. Read about Patisiran

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
ONPATTRO Concentrate for solution for infusion	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
N07XX12		N Nervous system → N07 Other nervous system drugs → N07X Other nervous system drugs → N07XX Other nervous system drugs
Discover more medicines within N07XX12

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: BR	Câmara de Regulação do Mercado de Medicamentos	Identifier(s): 587920070000107
Country: CA	Health Products and Food Branch	Identifier(s): 02489252
Country: EE	Ravimiamet	Identifier(s): 1779004
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 1181320001
Country: FR	Base de données publique des médicaments	Identifier(s): 62111751
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 374981
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8522
Country: IT	Agenzia del Farmaco	Identifier(s): 046993010
Country: JP	医薬品医療機器総合機構	Identifier(s): 1290400A1024
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1086213
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 196010
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100410723
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W64892001
Country: US	FDA, National Drug Code	Identifier(s): 71336-1000