PRONATIV

This brand name is authorized in New Zealand, Romania

Active ingredients

The drug PRONATIV contains a combination of these active pharmaceutical ingredients (APIs):

1 Coagulation factor II
UNII 25ADE2236L - THROMBIN
Read about Thrombin
2 Coagulation factor IX
UNII 6U90Y1795T - COAGULATION FACTOR IX HUMAN

Factor IX is a single chain glycoprotein with a molecular mass of about 68,000 Dalton. It is a vitamin-K dependent coagulation factor and it is synthesised in the liver. Factor IX is activated by factor XIa in the intrinsic coagulation pathway and by the factor VII/tissue factor complex in the extrinsic pathway. Activated factor IX, in combination with activated factor VIII, activates factor X.

Read about Coagulation factor IX
3 Coagulation factor VII
UNII 4156XVB4QD - COAGULATION FACTOR VII HUMAN
Read about Coagulation factor VII
4 Coagulation factor X
UNII 0P94UQE6SY - COAGULATION FACTOR X HUMAN

Coagulation factor X is derived from human plasma and used as a replacement for the naturally existing coagulation factor X in patients with hereditary factor X deficiency.

Read about Coagulation factor X
5
UNII 6D53G0FD0Z - PLASMA PROTEIN FRACTION (HUMAN)
Read about
6 Protein C
UNII 3Z6S89TXPW - PROTEIN C

Protein C is a serine protease with potent anticoagulant effects, especially in the presence of its cofactor protein S. Protein C exerts its effect by the inactivation of the activated forms of factors V and VIII which leads to a decrease in thrombin formation. Protein C has also been shown to have profibrinolytic effects.

Read about Protein C
7 Protein S
UNII 90J3F6N5FN - PROTEIN S HUMAN
Read about Protein S

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
B02BD01 Coagulation factor IX, II, VII and X in combination B Blood and blood forming organs → B02 Antihemorrhagics → B02B Vitamin K and other hemostatics → B02BD Blood coagulation factors
Discover more medicines within B02BD01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: NZ Medicines and Medical Devices Safety Authority Identifier(s): 12577
Country: RO Agenția Națională a Medicamentului și a Dispozitivelor Medicale Identifier(s): W65359002, W65360001

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