SINEMET

This brand name is authorized in United States. It is also authorized in Australia, Austria, Cyprus, Ecuador, Estonia, Finland, France, Germany, Ireland, Israel, Italy, Lithuania, Malta, Mexico, Netherlands, New Zealand, Poland, Singapore, South Africa, Spain, UK.

Active ingredients

The drug SINEMET contains a combination of these active pharmaceutical ingredients (APIs):

1	Carbidopa UNII MNX7R8C5VO - CARBIDOPA
	Carbidopa is a peripheral aromatic amino acid decarboxylase inhibitor. It prevents metabolism of levodopa to dopamine in the peripheral circulation, ensuring that a higher proportion of the dose reaches the brain, where dopamine exerts its therapeutic effects. A lower dose of levodopa can be used when it is coadministered with carbidopa, reducing the incidence and severity of peripheral side effects.
	Read more about Carbidopa
2	Levodopa UNII 46627O600J - LEVODOPA
	According to the current understanding, the symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatum. Dopamine does not cross the blood-brain barrier. Levodopa, the precursor of dopamine, crosses the blood brain barrier and relieves the symptoms of the disease.
	Read more about Levodopa

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
N04BA02	Levodopa and decarboxylase inhibitor	N Nervous system → N04 Anti-parkinson drugs → N04B Dopaminergic agents → N04BA Dopa and dopa derivatives
Discover more medicines within N04BA02

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
AU	Pharmaceutical Benefits Scheme	11890T, 1242J, 1245M, 1255C
DE	Bundesinstitut für Arzneimittel und Medizinprodukte	03117843, 03117978
EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	25.138-05-03
EE	Ravimiamet	1006861, 1006894, 1082517, 1560327, 1560338, 1560349, 1798072, 1799185
ES	Centro de información online de medicamentos de la AEMPS	51794, 55866, 59334, 59872
FI	Lääkealan turvallisuus- ja kehittämiskeskus	158447, 406372, 513203
FR	Base de données publique des médicaments	60092590, 66749235, 66818261, 69606865
GB	Medicines & Healthcare Products Regulatory Agency	140019, 143627, 147087, 147093, 162442, 162444, 175956, 181894, 181900, 211295, 211296, 211297, 24011, 24101, 377297, 377298
IE	Health Products Regulatory Authority	13296, 13297, 13300, 46105, 46111, 46159, 61601, 61623, 61674, 66902, 66912
IL	מִשְׂרַד הַבְּרִיאוּת	8247
IT	Agenzia del Farmaco	023145030, 023145042
LT	Valstybinė vaistų kontrolės tarnyba	1001763, 1001764, 1003483, 1003735, 1003920, 1087688, 1088351, 1090996, 1090997, 1090998, 1093502, 1093503, 1093504, 1093505
MT	Medicines Authority	AA565/12904
MX	Comisión Federal para la Protección contra Riesgos Sanitarios	82297
NL	Z-Index G-Standaard, PRK	14974, 15644, 25186, 31445, 34207
NZ	Medicines and Medical Devices Safety Authority	1819, 1820, 1821
PL	Rejestru Produktów Leczniczych	100061122
SG	Health Sciences Authority	07202P, 14601P
US	FDA, National Drug Code	0006-3915, 0006-3916, 0006-3917, 0006-3918, 0006-3919, 0006-6722, 0006-6723, 0006-6724
ZA	Health Products Regulatory Authority	F/5.4.1/56, P/5.4.1/141, Y/5.4.1/279