TECARTUS

This brand name is authorized in Austria, Canada, Estonia, France, Croatia, Ireland, Israel, Italy, Lithuania, Poland, United Kingdom, United States

Active ingredients

The drug TECARTUS contains one active pharmaceutical ingredient (API):

1 Brexucabtagene autoleucel UNII 4MD2J2T8SJ - BREXUCABTAGENE AUTOLEUCEL

Brexucabtagene autoleucel, a CD19-directed genetically modified autologous T-cell immunotherapy, binds to CD19 expressing cancer cells and normal B cells. Following anti-CD19 CAR T-cell engagement with CD19 expressing target cells, the CD28 co-stimulatory domain and CD3-zeta signalling domain activate downstream signalling cascades that lead to T-cell activation, proliferation, acquisition of effector functions and secretion of inflammatory cytokines and chemokines. This sequence of events leads to killing of CD19-expressing cells. Read about Brexucabtagene autoleucel

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
TECARTUS Dispersion for infusion	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01XL06		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XL Antineoplastic cell and gene therapy
Discover more medicines within L01XL06

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: CA	Health Products and Food Branch	Identifier(s): 02516667
Country: EE	Ravimiamet	Identifier(s): 1835074
Country: FR	Base de données publique des médicaments	Identifier(s): 60862404
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 393584
Country: IL	מִשְׂרַד הַבְּרִיאוּת	Identifier(s): 8804
Country: IT	Agenzia del Farmaco	Identifier(s): 049148012
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1091697
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100446081
Country: US	FDA, National Drug Code	Identifier(s): 71287-219, 71287-220