This brand name is authorized in Austria, Australia, Canada, Spain, France, Malta, Turkey, United Kingdom
The drug TOMUDEX contains one active pharmaceutical ingredient (API):
|
1
Raltitrexed
UNII 50VZN4BPUK - RALTITREXED DISODIUM
|
|
Raltitrexed is a folate analogue belonging to the family of anti-metabolites and has potent inhibitory activity against the enzyme thymidylate synthase (TS). Compared to other antimetabolites such as 5-fluorouracil or methotrexate, raltitrexed acts as a direct and specific TS inhibitor. TS is a key enzyme in the de novo synthesis of thymidine triphosphate (TTP), a nucleotide required exclusively for deoxyribonucleic acid (DNA) synthesis. Inhibition of TS leads to DNA fragmentation and cell death. |
Below package inserts are available for further reading:
| Title | Information Source | Document Type | |
|---|---|---|---|
| TOMUDEX Powder for solution for infusion | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01BA03 | Raltitrexed | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01B Antimetabolites → L01BA Folic acid analogues |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| Country: AU | Pharmaceutical Benefits Scheme | Identifier(s): 4610P, 7256X |
| Country: CA | Health Products and Food Branch | Identifier(s): 02229566 |
| Country: ES | Centro de información online de medicamentos de la AEMPS | Identifier(s): 61452 |
| Country: FR | Base de données publique des médicaments | Identifier(s): 60985360 |
| Country: GB | Medicines & Healthcare Products Regulatory Agency | Identifier(s): 73094 |
| Country: MT | Medicines Authority | Identifier(s): AA505/10201 |
| Country: TR | İlaç ve Tıbbi Cihaz Kurumu | Identifier(s): 8699643790038 |
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
