TORISEL

This brand name is authorized in Austria, Brazil, Canada, Croatia, Cyprus, Estonia, Finland, France, Ireland, Israel, Italy, Japan, Lithuania, Netherlands, Poland, Romania, Singapore, South Africa, Spain, Turkey, UK.

Active ingredients

The drug TORISEL contains one active pharmaceutical ingredient (API):

1	Temsirolimus UNII 624KN6GM2T - TEMSIROLIMUS
	Temsirolimus is a selective inhibitor of mTOR (mammalian target of rapamycin). Temsirolimus binds to an intracellular protein (FKBP-12), and the protein/temsirolimus complex binds and inhibits the activity of mTOR that controls cell division. In vitro, at high concentrations (10-20 M), temsirolimus can bind and inhibit mTOR in the absence of FKBP-12. When mTOR activity is inhibited, its ability to phosphorylate, and thereby control the activity of protein translation factors (4E-BP1 and S6K, both downstream of mTOR in the P13 kinase/AKT pathway) that control cell division, is blocked.
	Read more about Temsirolimus

Medication package inserts

Below package inserts are available for further reading:

Document	Type	Information Source
TORISEL Concentrate and solvent for solution for infusion	MPI, EU: SmPC	European Medicines Agency (EU)

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC Group		Classification
L01EG01	Temsirolimus	L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EG Mammalian target of rapamycin (mTOR) kinase inhibitors
Discover more medicines within L01EG01

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
BR	Câmara de Regulação do Mercado de Medicamentos	522720050087217
CA	Health Products and Food Branch	02304104
EE	Ravimiamet	1342303
ES	Centro de información online de medicamentos de la AEMPS	07424001
FI	Lääkealan turvallisuus- ja kehittämiskeskus	061715
FR	Base de données publique des médicaments	60443413
GB	Medicines & Healthcare Products Regulatory Agency	146030
IL	מִשְׂרַד הַבְּרִיאוּת	6993
IT	Agenzia del Farmaco	038327019
JP	医薬品医療機器総合機構	4291418A1025
LT	Valstybinė vaistų kontrolės tarnyba	1031298
NL	Z-Index G-Standaard, PRK	85022
PL	Rejestru Produktów Leczniczych	100181790
RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	W64785001
SG	Health Sciences Authority	13729P
TR	İlaç ve Tıbbi Cihaz Kurumu	8681308777621
ZA	Health Products Regulatory Authority	42/26/0227