This brand name is authorized in United States.
The drug TRIJARDY XR contains a combination of these active pharmaceutical ingredients (APIs):
1
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UNII
HDC1R2M35U - EMPAGLIFLOZIN
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Empagliflozin is a reversible, highly potent (IC50 of 1.3 nmol) and selective competitive inhibitor of sodium-glucose co-transporter 2 (SGLT2). Empagliflozin improves glycaemic control in patients with type 2 diabetes by reducing renal glucose reabsorption. |
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2
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UNII
3X29ZEJ4R2 - LINAGLIPTIN
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Linagliptin is an inhibitor of the enzyme DPP-4 (dipeptidyl peptidase 4, EC 3.4.14.5) an enzyme which is involved in the inactivation of the incretin hormones GLP-1 and GIP (glucagon-like peptide1, glucose-dependent insulinotropic polypeptide). These hormones are rapidly degraded by the enzyme DPP-4. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. |
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3
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UNII
786Z46389E - METFORMIN HYDROCHLORIDE
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Metformin is a biguanide with antihyperglycaemic effects, lowering both basal and postprandial plasma glucose. It does not stimulate insulin secretion and therefore does not produce hypoglycaemia. |
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Below package inserts are available for further reading:
| Document | Type | Information Source | |
|---|---|---|---|
| TRIJARDY XR Extended-release tablet | MPI, US: SPL/PLR | FDA, National Drug Code (US) |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| US | FDA, National Drug Code | 0597-0380, 0597-0385, 0597-0390, 0597-0395 |
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