VARGATEF

This brand name is authorized in Austria, Cyprus, Ecuador, Estonia, Spain, France, Hong Kong, Croatia, Ireland, Italy, Lithuania, Netherlands, Poland, Romania, Turkey, United Kingdom

Active ingredients

The drug VARGATEF contains one active pharmaceutical ingredient (API):

1 Nintedanib UNII G6HRD2P839 - NINTEDANIB

Nintedanib is a triple angiokinase inhibitor blocking vascular endothelial growth factor receptors (VEGFR 1-3), platelet-derived growth factor receptors (PDGFR α and β) and fibroblast growth factor receptors (FGFR 1-3) kinase activity. Nintedanib binds competitively to the adenosine triphosphate (ATP) binding pocket of these receptors and blocks the intracellular signalling which is crucial for the proliferation and survival of endothelial as well as perivascular cells (pericytes and vascular smooth muscle cells). Read about Nintedanib

Medication package inserts

Below package inserts are available for further reading:

Title	Information Source	Document Type
VARGATEF Soft capsule	European Medicines Agency (EU)	MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code	Group title	Classification
L01EX09		L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01E Protein kinase inhibitors → L01EX Other protein kinase inhibitors
Discover more medicines within L01EX09

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country	Identification scheme	Identifier(s)
Country: EC	Agencia Nacional de Regulación, Control y Vigilancia Sanitaria	Identifier(s): 1235-MEE-0815, 1303-MEE-0915
Country: EE	Ravimiamet	Identifier(s): 1670677, 1670688, 1670699
Country: ES	Centro de información online de medicamentos de la AEMPS	Identifier(s): 114954003, 114954004
Country: FR	Base de données publique des médicaments	Identifier(s): 65642038, 69324684
Country: GB	Medicines & Healthcare Products Regulatory Agency	Identifier(s): 287824, 287827
Country: HK	Department of Health Drug Office	Identifier(s): 64395, 64396
Country: IE	Health Products Regulatory Authority	Identifier(s): 88458, 88459
Country: IT	Agenzia del Farmaco	Identifier(s): 043782010, 043782022, 043782034, 043782046
Country: LT	Valstybinė vaistų kontrolės tarnyba	Identifier(s): 1075089, 1075090, 1075091, 1075092
Country: NL	Z-Index G-Standaard, PRK	Identifier(s): 122750, 127337
Country: PL	Rejestru Produktów Leczniczych	Identifier(s): 100332696, 100332704
Country: RO	Agenția Națională a Medicamentului și a Dispozitivelor Medicale	Identifier(s): W61687001, W61687002, W61687003, W61688001
Country: TR	İlaç ve Tıbbi Cihaz Kurumu	Identifier(s): 8699693190048, 8699693190055, 8699693190062