VASCULFLOW

Diosmin (diosmetin 7-O-rutinoside), a flavone derivative also known as venosmine, is a glycoside of diosmetin, which in turn is the 4'-methoxy derivative of luteolin. Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and venous stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.

Calcium dobesilate is a regulator of capillary functions. Calcium dobesilate acts on the capillary walls by regulating its impaired physiological functions – increased permeability and decreased resistance. It increases erythrocyte flexibility, inhibits platelet hyperaggregation and, in diabetic retinopathy, it reduces plasma and blood hyperviscosity, thus improving blood rheological properties and tissue irrigation.