ZEVALIN

This brand name is authorized in Austria, Cyprus, Estonia, Spain, Finland, Hong Kong, Ireland, Japan, Lithuania, Poland, United Kingdom, South Africa

Active ingredients

The drug ZEVALIN contains one active pharmaceutical ingredient (API):

1 Ibritumomab tiuxetan (⁹⁰Y)
UNII 4Q52C550XK - IBRITUMOMAB TIUXETAN

Ibritumomab tiuxetan (⁹⁰Y) is a recombinant murine IgG1 kappa monoclonal antibody specific for the B-cell antigen CD20. Ibritumomab tiuxetan targets the antigen CD20 which is located on the surface of malignant and normal B-lymphocytes. During B-cell maturation, CD20 is first expressed in the midstage of B-lymphoblast (pre-B-cell), and is lost during the final stage of B-cell maturation to plasma cells. It is not shed from the cell surface and does not internalise on antibody binding.

Medication package inserts

Below package inserts are available for further reading:

Title Information Source Document Type  
ZEVALIN Kit for radiopharmaceutical preparations for infusion European Medicines Agency (EU) MPI, EU: SmPC

Medicine classification

This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:

ATC code Group title Classification
L01XC † Monoclonal antibodies L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents
Discover more medicines within L01XC
V10XX02 Ibritumomab tiuxetan [90Y] V Various → V10 Therapeutic radiopharmaceuticals → V10X Other therapeutic radiopharmaceuticals → V10XX Various therapeutic radiopharmaceuticals
Discover more medicines within V10XX02

Authorization and marketing

This drug has been assigned below unique identifiers within the countries it is being marketed:

Country Identification scheme Identifier(s)
Country: EE Ravimiamet Identifier(s): 1208203, 1811236
Country: ES Centro de información online de medicamentos de la AEMPS Identifier(s): 03264001
Country: FI Lääkealan turvallisuus- ja kehittämiskeskus Identifier(s): 015623
Country: GB Medicines & Healthcare Products Regulatory Agency Identifier(s): 397977
Country: HK Department of Health Drug Office Identifier(s): 54925
Country: JP 医薬品医療機器総合機構 Identifier(s): 4291414G1020, 4300450G1027
Country: LT Valstybinė vaistų kontrolės tarnyba Identifier(s): 1031487
Country: PL Rejestru Produktów Leczniczych Identifier(s): 100126554
Country: ZA Health Products Regulatory Authority Identifier(s): A39/35/0016

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