This brand name is authorized in United States. It is also authorized in Austria, Canada, Croatia, Estonia, France, Ireland, Italy, Lithuania, Netherlands, New Zealand, Poland, Romania, Spain, Turkey, UK.
The drug ZIRABEV contains one active pharmaceutical ingredient (API):
1
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UNII
2S9ZZM9Q9V - BEVACIZUMAB
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Bevacizumab binds to vascular endothelial growth factor (VEGF), the key driver of vasculogenesis and angiogenesis, and thereby inhibits the binding of VEGF to its receptors, Flt-1 (VEGFR-1) and KDR (VEGFR-2), on the surface of endothelial cells. Neutralising the biological activity of VEGF regresses the vascularisation of tumours, normalises remaining tumour vasculature, and inhibits the formation of new tumour vasculature, thereby inhibiting tumour growth. |
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This drug has been classified in the anatomical therapeutic chemical (ATC) classification system as follows:
| ATC Group | Classification | |
|---|---|---|
| L01FG01 | Bevacizumab | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01F Monoclonal antibodies and antibody drug conjugates → L01FG VEGF/VEGFR (Vascular Endothelial Growth Factor) inhibitors |
This drug has been assigned below unique identifiers within the countries it is being marketed:
| Country | Identification scheme | Identifier(s) |
|---|---|---|
| CA | Health Products and Food Branch | 02489430, 02489449 |
| EE | Ravimiamet | 1789432, 1789443 |
| ES | Centro de información online de medicamentos de la AEMPS | 1181344001, 1181344002 |
| FR | Base de données publique des médicaments | 64224872 |
| GB | Medicines & Healthcare Products Regulatory Agency | 384843, 384855 |
| IT | Agenzia del Farmaco | 047629011, 047629023 |
| LT | Valstybinė vaistų kontrolės tarnyba | 1087076, 1087077 |
| NL | Z-Index G-Standaard, PRK | 76910, 76929 |
| NZ | Medicines and Medical Devices Safety Authority | 21604 |
| PL | Rejestru Produktów Leczniczych | 100416884 |
| RO | Agenția Națională a Medicamentului și a Dispozitivelor Medicale | W66686001, W66686002 |
| TR | İlaç ve Tıbbi Cihaz Kurumu | 8681308771087, 8681308771094 |
| US | FDA, National Drug Code | 0069-0315, 0069-0342 |
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