ICD-10 Specific code L57.0: Actinic keratosis
Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.
Translations
| Language | Translation |
|---|---|
English
|
Actinic keratosis |
French
|
Kératose actinique |
Hierarchical position
| Level | Code | Title | |
|---|---|---|---|
| 1 | XII | Diseases of the skin and subcutaneous tissue | |
| 2 | L55-L59 | Radiation-related disorders of the skin and subcutaneous tissue | |
| 3 | L57 | Skin changes due to chronic exposure to nonionizing radiation | |
| 4 | L57.0 | Actinic keratosis |
Indicated medicines
| Active Ingredient |
|---|
|
5-Aminolevulinic acid (5-ALA) is a natural biochemical precursor of heme that is metabolised in a series of enzymatic reactions to fluorescent porphyrins, particularly PPIX. 5-ALA synthesis is regulated by an intracellular pool of free heme via a negative feedback mechanism. Administration of excess exogenous 5-ALA avoids the negative feedback control, and accumulation of PPIX occurs in target tissue. In the presence of visible light, fluorescence of PPIX (photodynamic effect) in certain target tissues can be used for photodynamic diagnosis. |
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Dexpanthenol is converted in tissues to pantothenic acid, a component of coenzyme A (CoA) that is essential to normal epithelial function, increased fibroblast proliferation and accelerated re-epithelialization in wound healing. |
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Picato is indicated for the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults. The mechanism of action of ingenol mebutate for use in actinic keratosis remains to be fully characterised. Results from two clinical studies on biological effects of ingenol mebutate have shown that topical administration induced epidermal necrosis and a profound inflammatory response in both epidermis and the upper dermis of the treated skin, dominated by infiltrating T cells, neutrophils and macrophages. |