Specific codes in ICD-10 are unique alphanumeric designations used to identify and categorize diseases, disorders, and conditions. They consist of 3-5 characters, including both letters and numbers, that provide a high level of detail and specificity.
Language | Translation |
---|---|
English | Achondroplasia |
French | Achondroplasie |
Level | Code | Title | |
---|---|---|---|
1 | XVII | Congenital malformations, deformations and chromosomal abnormalities | |
2 | Q65-Q79 | Congenital malformations and deformations of the musculoskeletal system | |
3 | Q77 | Osteochondrodysplasia with defects of growth of tubular bones and spine | |
4 | Q77.4 | Achondroplasia |
Active Ingredient | Description | |
---|---|---|
Vosoritide |
Vosoritide is a modified type C natriuretic peptide (CNP). In patients with achondroplasia, endochondral bone growth is negatively regulated due to a gain of function mutation in fibroblast growth factor receptor 3 (FGFR3). Binding of vosoritide to natriuretic peptide receptor-B (NPR-B) antagonises FGFR3 downstream signalling. As a result, vosoritide, like CNP, acts as a positive regulator of endochondral bone growth as it promotes chondrocyte proliferation and differentiation. |