Hepatocellular carcinoma (HCC)

Active Ingredient: Ramucirumab

Indication for Ramucirumab

Population group: only adults (18 years old or older)

Ramucirumab monotherapy is indicated for the treatment of adult patients with advanced or unresectable hepatocellular carcinoma who have a serum alpha fetoprotein (AFP) of ≥400 ng/ml and who have been previously treated with sorafenib.

For this indication, competent medicine agencies globally authorize below treatments:

8 mg/kg once every 2 weeks

Route of admnistration

Intravenous

Defined daily dose

8 - 8 mg per kg of body weight

Dosage regimen

From 8 To 8 mg per kg of body weight once every 15 day(s)

Detailed description

The recommended dose of ramucirumab as a single agent is 8 mg/kg every 2 weeks.

Alpha fetoprotein (AFP) testing in HCC

Patients with HCC should be selected based on a serum AFP concentration of ≥400 ng/ml with a validated AFP test prior to ramucirumab treatment.

Active ingredient

Ramucirumab

Ramucirumab is a human receptor-targeted antibody that specifically binds VEGF Receptor 2 and blocks binding of VEGF-A, VEGF-C, and VEGF-D. Vascular Endothelial Growth Factor (VEGF) Receptor 2 is the key mediator of VEGF induced angiogenesis. As a result, ramucirumab inhibits ligand stimulated activation of VEGF Receptor 2 and its downstream signalling components, including p44/p42 mitogen-activated protein kinases, neutralising ligand-induced proliferation and migration of human endothelial cells.

Read more about Ramucirumab

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