Indication for Terazosin

Population group: Suitable for both men and women, only adults (18 years old or older)
Therapeutic intent: Curative procedure

Orally administered terazosin is indicated in adults for the treatment of mild to moderate hypertension. It may be used in combination with thiazide diuretics and/or other antihypertensive drugs or as sole therapy where other agents are inappropriate or ineffective. The hypotensive effect is most pronounced on the diastolic pressure.

For this indication, competent medicine agencies globally authorize below treatments:

1 mg once daily and 2-10 mg once daily thereafter

For: Adults (18-64) Elders (65+)

Dosage regimens

Oral, 1 milligrams, once daily at the end of the day, over the duration of 1 week. Afterwards, oral, between 1 and 5 milligrams, 1 to 2 times daily. The maximum allowed total dose is 20 milligrams daily.

Detailed description

Initial dose: 1mg before bedtime is the starting dose for all patients and should not be exceeded. Compliance with this initial dosage recommendation should be strictly observed to minimise potential for acute first-dose hypotensive episodes.

Subsequent doses: the single daily dosage may be increased by approximately doubling the dosage at weekly intervals to achieve the desired blood pressure response.

The usual maintenance dose is 2mg to 10mg once daily. Doses over 20mg rarely improve efficacy and doses over 40mg have not been studied.

Dosage considerations

Before bedtime.

Active ingredient

Although the exact mechanism of the hypotensive action is not established, the relaxation of peripheral blood vessels appears to be produced mainly by competitive antagonism of post-synaptic alpha-adrenoceptors. Terazosin usually produces an initial gradual decrease in blood pressure followed by a sustained antihypertensive action.

Read more about Terazosin

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