For this indication, competent medicine agencies globally authorize below treatments:
200 - 600 mg per m² of body surface area (BSA)
From 200 To 600 mg per m² of body surface area (BSA) once every day
5-fluorouracil is used in the treatment of colon and rectal cancers in a number of treatment regimens. 5-fluorouracil is preferably used along with folinic acid. Commonly used treatment regimens also combine 5-fluorouracil and folinic acid with other chemotherapeutic agents such as Irinotecan (FOLFIRI and FLIRI), Oxaliplatin (FOLFOX) or both Irinotecan and Oxaliplatin (FOLFIRINOX).
The commonly used dose range of 5-fluorouracil varies from 200-600mg/m² of body surface. The dose also varies depending administration as intravenous bolus or as continuous intravenous infusion.
The dose schedules also vary depending on the chemotherapy regimen, and 5-fluorouracil dose could be repeated weekly, bimonthly or monthly.
The number of cycles varies with the treatment regimens used and also depends on the clinical decision based on treatment success and tolerability.