Colorectal cancer

Active Ingredient: Fluorouracil

Indication for Fluorouracil

Population group: only adults (18 years old or older)

For this indication, competent medicine agencies globally authorize below treatments:

200-600 mg/m²

Route of admnistration

Intravenous

Defined daily dose

200 - 600 mg per m² of body surface area (BSA)

Dosage regimen

From 200 To 600 mg per m² of body surface area (BSA) once every day

Detailed description

5-fluorouracil is used in the treatment of colon and rectal cancers in a number of treatment regimens. 5-fluorouracil is preferably used along with folinic acid. Commonly used treatment regimens also combine 5-fluorouracil and folinic acid with other chemotherapeutic agents such as Irinotecan (FOLFIRI and FLIRI), Oxaliplatin (FOLFOX) or both Irinotecan and Oxaliplatin (FOLFIRINOX).

The commonly used dose range of 5-fluorouracil varies from 200-600mg/m² of body surface. The dose also varies depending administration as intravenous bolus or as continuous intravenous infusion.

The dose schedules also vary depending on the chemotherapy regimen, and 5-fluorouracil dose could be repeated weekly, bimonthly or monthly.

The number of cycles varies with the treatment regimens used and also depends on the clinical decision based on treatment success and tolerability.

Active ingredient

Fluorouracil
Fluorouracil is an antineoplastic anti-metabolite. Anti-metabolites masquerade as purine or pyrimidine – which become the building blocks of DNA. They prevent these substances from becoming incorporated into DNA during the “S” phase (of the cell cycle), stopping normal development and division. Fluorouracil blocks an enzyme which converts the cytosine nucleotide into the deoxy derivative. In addition, DNA synthesis is further inhibited because Fluorouracil blocks the incorporation of the thymidine nucleotide into the DNA strand. Fluorouracil is used for the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid. Read more about Fluorouracil

Related medicines

Summary of Product Characteristics (SPC) 2019: EFUDIX Cream

Summary of Product Characteristics (SPC) 2019: FLUOROURACIL Solution for injection or infusion

Structured Product Labeling (SPL) 2020: EFUDEX Topical solution / Cream

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.