Active Ingredient: Benralizumab
Benralizumab is indicated as an add-on treatment for adult and adolescent patients aged 12 years and older weighing at least 35 kg with inadequately controlled hypereosinophilic syndrome without an identifiable non-haematologic secondary cause.
For this indication, competent medicine agencies globally authorize below treatments:
For:
In the case that patient weight is ≥ 35 kg :
Subcutaneous, 30 milligrams benralizumab, once every 4 weeks.
Benralizumab is intended for long-term treatment. A decision to continue the therapy should be made at least annually based on disease severity, level of disease control and blood eosinophil counts.
The recommended dose of benralizumab for adult and adolescent patients aged 12 years and older weighing at least 35 kg is 30 mg by subcutaneous injection every 4 weeks.
Patients who develop life-threatening manifestations of HES should be evaluated for the need for continued therapy, as Fasenra has not been studied in this population.
If an injection is missed on the planned date, dosing should resume as soon as possible on the indicated regimen; a double dose must not be administered.
Benralizumab should be injected into the thigh or abdomen, except for the 5 cm area around the navel. If the healthcare professional or caregiver administers the injection, the upper arm can also be used. It should not be injected into areas where the skin is tender, bruised, erythematous, or hardened.
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