Active Ingredient: Zilucoplan
Zilucoplan is indicated as an add-on to standard therapy for the treatment of generalised myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient weight is ≤ 56 kg, subcutaneous, 16.6 milligrams zilucoplan, once daily.
Regimen B: In case that patient weight is ≥ 6 kg and patient weight is ≤ 77 kg, subcutaneous, 23 milligrams zilucoplan, once daily.
Regimen C: In case that patient weight is ≥ 77 kg, subcutaneous, 32.4 milligrams zilucoplan, once daily.
Before starting therapy, patients must be vaccinated against Neisseria meningitidis. If treatment needs to start less than 2 weeks after vaccination, the patient must receive appropriate prophylactic antibiotic treatment until 2 weeks after the first vaccination dose.
The recommended dose should be given as a subcutaneous injection once daily and administered about the same time every day.
Total daily dose by body weight range:
| Body weight | Dose* |
|---|---|
| <56 kg | 16.6 mg |
| ≥56 to <77 kg | 23 mg |
| ≥77 kg | 32.4 mg |
* The recommended dose corresponds to approximately 0.3 mg/kg.
Zilucoplan has not been studied in gMG patients with a Myasthenia Gravis Foundation of America (MGFA) Class V.
If a dose is missed, it should be administered the same day; then, normal dosing should be continued the following day. No more than one dose should be administered per day.
Administered by subcutaneous injection.
Suitable injection sites include front of the thighs, abdomen and the back of the upper arms.
Injection sites should be rotated and injections should not be given in areas where the skin is tender, erythematous, bruised, indurated or where the skin has scars or stretch marks.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
